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Home - Products - Cell Cycle/DNA Damage - Topoisomerase - Idarubicin hydrochloride

Idarubicin hydrochloride

CAS No. 57852-57-0

Idarubicin hydrochloride ( 4-Demethoxydaunorubicin hydrochloride )

Catalog No. M15119 CAS No. 57852-57-0

An anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Idarubicin hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    An anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.
  • Description
    An anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells; inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM; also induces histone eviction from chromatin.Chemotherapeutic Agents Approved
  • Synonyms
    4-Demethoxydaunorubicin hydrochloride
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    Multicellular spheroids; Topo II (MCF-7 cells)
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    57852-57-0
  • Formula Weight
    533.95
  • Molecular Formula
    C26H28ClNO9
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1C2=C(O)C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@](O)(C(C)=O)C4)=C4C(O)=C2C(C5=C1C=CC=C5)=O.[H]Cl
  • Chemical Name
    5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride (1:1), (7S,9S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gewirtz DA, et al. Cancer Chemother Pharmacol. 1998;41(5):361-9.
2. Pang B, et al. Nat Commun. 2013;4:1908.
3. Nitiss JL. Nat Rev Cancer. 2009 May;9(5):338-50.
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